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III. Meningitis (Leptomeningitis)

C. Pathological changes (cont):

3. Chronic meningitis - caused by fungi (e.g., candidiasis, cryptococcosis), tubercle bacillus (tuberculosis), T. pallidum (syphilis):

  • Exudate, mononuclear infiltrate with lymphocytes, mononuclear cells, small tubercles (caseous necrosis surrounded by epithelioid cells and giant cells, peripheral ring of lymphocytes)
  • Localized over base of brain
  • Vasculitis common


Exudate concentrated at the base of the brain is seen here. The exudate may infiltrate cranial nerves
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