IX. Subacute Sclerosing Panencephalitis (SSPE)
A. Clinical features
Onset: 5‑20 years of age. The disease occurs in children or young adults, months or years after an initial, early-age acute infection with measles.
Clinical presentation: personality changes, intellectual deterioration; seizures, spasticity of limbs
Duration: death usually in several years
CSF changes: elevated gamma globulin; antibody titer against measles is elevated
Persistent but nonproductive infection of the CNS by altered measles virus.