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IX. Subacute Sclerosing Panencephalitis (SSPE)

A. Clinical features

Onset: 5‑20 years of age. The disease occurs in children or young adults, months or years after an initial, early-age acute infection with measles.

Clinical presentation:  personality changes, intellectual deterioration;  seizures, spasticity of limbs

Duration:  death usually in several years

CSF changes:  elevated gamma globulin; antibody titer against measles is elevated

B. Pathogenesis

Persistent but nonproductive infection of the CNS by altered measles virus.