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IIIB. Oligodendrocytes - pathological changes

B. Pathological reactions

Oligodendrocytes swell in response to almost any type of toxic or metabolic change. Diseases with primary involvement of oligodendrocytes result in disorders of myelin, with demyelination or abnormal myelin formation. The two major groups of diseases affecting oligodendrocytes and myelin are the leukodystrophies, which include inherited disorders of myelin metabolism, and the acquired demyelinating diseases (e.g. multiple sclerosis).