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IIB. Astrocytes - pathological changes

B. Pathological reactions

In the brain, repair and glial scar formation is mainly accomplished by gliosis. (Fibrosis and formation of fibrous scar tissue does not generally occur in the brain.) Gliosis involves proliferation of astrocytes with formation of many glial processes. Some astrocytes become gemistocytic, i.e. they appear plump or swollen and the cytoplasm is eosinophilic.

 

 

A gemistocytic astrocyte is shown in the center of the image. Note the plump, swollen eosinophilic cytoplasm around a healthy nucleus.
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