II. Multiple Sclerosis Variants

Multiple Sclerosis Variants and Other Types of Encephalomyelitis Demyelinating Diseases:

Multiple Sclerosis variants: Examples include:

• Neuromyelitis optica (also called Devic disease) - more prevalent in Asians: the course is variable
• Acute MS ( Marburg form) - tends to occur in young individuals; rapid course over several months

Acute Disseminated encephalomyelitis (ADEM, perivenous encephalomyelitis)

• Demyelinating disease that usually follows a viral infection; diffuse brain involvement; prognosis ranges from death to complete recovery

Acute Necrotizing Hemorrhagic Encephalomyelitis (ANHE)

• Rapidly progressing syndrome of CNS demyelination; usually preceded by upper respiratory infection; more common in young adults and children; prognosis ranges from death to complete recovery; lesions are more devastating than ADEM and include disseminated necrosis with acute hemorrhage