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MSU College of Osteopathic Medicine

Objectives: Inherited Metabolic Disorders

For each of the following diseases

  • Tay-Sachs disease
  • Niemann-Pick disease type A
  • Metachromatic Leukodystrophy
  • Krabbe Leukodystrophy

the student should be able to:

1. Classify each as a neuronal storage disease (primarily gray matter) or a leukodystrophy (primarily white matter)

2. Describe clinical presentation, course of the disease, criteria for diagnosis, and pathological changes