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II. Lysosomal storage diseases

Examples of pathology

Myelin deficits in Krabbe disease and metachromatic leukodystrophy

This luxol fast blue-stained section shows hypomyelination in the white matter in Krabbe disease. The lateral ventricle is at the top. The absence of dark blue staining in much of the periventricular white matter indicate the absence of myelin. Note that the U-fibers adjacent to the cortical gyri have normal myelin.

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