Case 7: Question 1

A 66-year-old man woke up one morning and could not move his right arm or hand. He had trouble trying to speak to his wife, but could understand her questions and follow her directions. At the hospital, neurological exam revealed the following abnormalities:

• paralysis of right lower face muscles (but he could wrinkle his forehead on both sides)
• paralysis and hyperreflexia of right hand and arm
• mild sensory loss (both modalities) in right hand, arm and face
• Broca's aphasia

Question 1: What is the most likely location for a lesion?