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MSU College of Osteopathic Medicine

Objectives: Toxic, Nutritional, Acquired Metabolic Disorders

For each of the following entities the student should be able to:

1. Describe the etiology/pathogenesis and/or pathophysiology, gross and microscopic morphology and distribution of the lesions whenever possible

2. List clinical signs and symptoms

  • Lead poisoning
  • Carbon monoxide toxicity
  • Methanol toxicity
  • Wernicke's encephalopathy & Korsakoff's syndrome (thiamine/vitamin B1 deficiency)
  • Subacute combined degeneration (B12 deficiency)
  • Kernicterus (bilirubin toxicity)
  • Hepatic encephalopathy