IV. Spinal Cord Lesions
C. Clinical signs
Neurological symptoms vary from complete loss of function below the injured segments to temporary loss of cord function with complete recovery. Specific symptoms depend on the site of injury. After denervation, fibrillations, fasciculations, muscle atrophy, and groups of atrophic fibers in a muscle biopsy will be seen.
D. Pathological changes
The most common pathological changes are contusions, with necrosis, swelling and hemorrhage acutely to variable extents. Chronic changes include macrophages, gliosis and loss of architecture. Wallerian degeneration in distal axons (distal to the neuron cell body) will occur.